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Structure of Silica Gel

- Inorganic macropolymer made of [SiO4]4- tetrahedra

- Polar Si-OH (silanols) groups on the surface

Functionalized Silica Gels 

- Functional moieties grafted on the silanol groups (-OH) of silica

- End-capping of residual (-OH) to remove binding capacity

- No non-specific binding

- High yields

Advantage over Polymer:

- Consistent Loading Lot-to-Lot

- Rigid Porous Structure; No swelling, Solvent Independent and Fast kinetics

-Easily Scalable. works on the microgram to the multi-ton scale