Structure of Silica Gel
- Inorganic macropolymer made of [SiO4]4- tetrahedra
- Polar Si-OH (silanols) groups on the surface



Functionalized Silica Gels 
- Functional moieties grafted on the silanol groups (-OH) of silica
- End-capping of residual (-OH) to remove binding capacity
- No non-specific binding
- High yields

Advantage over Polymer:

- Consistent Loading Lot-to-Lot

- Rigid Porous Structure; No swelling, Solvent Independent and Fast kinetics

-Easily Scalable. works on the microgram to the multi-ton scale

- Easier to Handle; Free flowing, No static Charge. It does not require extensive washing for high recoveries and will not stick to glasware. Easy to Automate.
- Higher Density; Small volume of Silica required

SiliaBond® alphabetical listing:
SiliaBond C1- R33030B
SiliaBond C4- R32130B
SiliaBond C8-R31030B-R30830B
SiliaBond C12 (Adamantyl)
SiliaBond C18-R33230B-R33330B-R33530B-R00030B-R00130B-R02130B-R00430B-R53030B
SiliaBond Allyl-R53530B
SiliaBond Aluminium Chloride -R74530B
SiliaBond Amine-R52030B
SiliaBond Bromophenyl-R55030B
SiliaBond Carbodiimide
SiliaBond Carbonate
SiliaBond Carboxylic Acid
SiliaBond Cyano- R38030B
SiliaBond Cyanoborohydride
SiliaBond Cyclohexyl
SiliaBond Cysteine-R80530B
SiliaBond Diamine
SiliaBond Dichlorotriazine
SiliaBond Diethylamine
SiliaBond Dimethylamine
SiliaBond Diol
SiliaBond Diphenylphosphine
SiliaBond DMAP
SiliaBond DMT
SiliaBond Fluorochrom
SiliaBond Glycidoxy
SiliaBond Imidazole
SiliaBond Isocyanate
SiliaBond Maleimide
SiliaBond Morpholine
SiliaBond Pentafluorophenyl
SiliaBond Phenyl
SiliaBond Phenylmethylchloride
SiliaBond Piperazine
SiliaBond Piperidine
SiliaBond Potassium Permanganate
SiliaBond Propyl Bromide
SiliaBond Propylsulfonic Acid
SiliaBond Pyridine
SiliaBond Pyridinium Chlorochromate
SiliaBond Pyridinium Dichromate
SiliaBond Silver Nitrate (AgNO3)-R23530B
SiliaBond TAAcOH-R69030B
SiliaBond TAAcONa
SiliaBond TBA Chloride
SiliaBond TBD
SiliaBond Thiol
SiliaBond Thiourea
SiliaBond Tin Hydride
SiliaBond TMA Acetate
SiliaBond TMA Chloride
SiliaBond Tosic Acid
SiliaBond Tosyl Chloride
SiliaBond Tosyl Hydrazine
SiliaBond Triamine
SiliaBond Tridecafluoro
SiliaBond Urea-R6730B

Thermal Stability (Comparing Silica to Polystyrene (PS) resin)
Most functional Silica's can withstand temperatures of over 200°C and are suitable for use in microwave synthesizers.
1. SiliaBond  C1 stirred for 4h at 110°C in Toluene
2. PS resin stirred for  1h at 110°C in Toluene








Mechanical Stability; Works well with overhead stirring and can be used with a bottom coupled spin bar for up to four hours.
Limits of Use
Si-O-Si bond susceptible to hydrolysis  under certain conditions:
- Aqueous solution at high or very low pH
- Keep the pH between 2 and 12 when using water












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