Metal

Removing residual transition metal post reaction is a major issue for many chemists, particularly process chemists in the pharmaceutical industry, where the toxic nature of transition metals means their concentration has to be reduced to the single digit ppm level for the material to be used in vivo and clinical work. SiliCycle has a wide range of scavengers that can remove a variety of transition metals

When selecting a metal scavenger for your reaction every component in the reaction mixture must be considered; the solvent and ligand are key factors but the product, residual reagents, and by-products can all affect scavenger performance. Please view our case study on Pd removal for more information.

Metal Scavenger Selection Guide

Removing residual transition metal post reaction is a major issue for many chemists, particularly process chemists in the pharmaceutical industry, where the toxic nature of transition metals means their concentration has to be reduced to the single digit ppm level for the material to be used in vivo and clinical work. SiliCycle has a wide range of scavengers that can remove a variety of transition metals (Table 1).

When selecting a metal scavenger for your reaction every component in the reaction mixture must be considered; the solvent and ligand are key factors but the product, residual reagents, and by-products can all affect scavenger performance. Please view our case study on Pd removal for more information.

Scavenger Pd(II) Pd(0) Sn Zn Pb Ni(II) Ni(0) Pt Cu Cd Co Rh Ru Ag Hg
Si-Amine
v
v
v
*
Si-Diamine
v
v
v
v
vv
Si- Triamine
v
*
v
v
Si-Thiol
*
v
+
*
*
*
Si-EDAB
+
Si-TAAcOH
*
*
Si-TAAcONa
v
*
v
Si-Thiourea
v
v
v
+
+
+
Si-TBD
v
+

*: Preferred Product , v: Scavenges, +: Reported in the literature or by customers



Part number - Name Description - Loading


R48030B - Si-Triamine Metal Scavenger: Pb, Ru, Co, Hg, and Pd. 1.3 mmol / g

R49030B - Si-Diamine Metal Scavenger: Zn, Ni(II), Pb, Cd, Hg 1.4 mmol / g

R51030B - Si-Thiol Metal Scavenger: Pd, Pt, Cu, Ag, and Pb 1.2 mmol / g

R69030B - SiliaBond TAAcOH Acid and Metal Scavenger 0.5 mmol / g

R69230B - Si-TAAcONa Metal Scavenger: Pd(II), Ni(II), Cu(II) 0.5 mmol / g

R69530B - Si-Thiourea Metal Scavenger: Pd, Pt, Rh, Ru, Hg 1.1 mmol / g



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