Program/Time Februari 9, 2010.
10:00 - 10:30 Welcome / Coffee / Introduction
10:30 - 11:15 Dr. Francois Béland, "Silica gel: from the earth to the lab"
11:15 - 12:00 Prof. André de Haan (TU Eindhoven);" Functionalized Silica's for Homogeneous Catalyst Recovery and Recycling"
12:10 - 13:00 Lunch
13:00 - 13:40 Ing. Henkjan van Lent (MSD), "Purifications in Process Chemistry"
13:40 - 14:20 Ing. Hans Colstee (IFF), "Extraction, separation and concentration of watery flavour Distillates using column extraction"
14:20 - 14:40 Coffee Break
14:40 - 15:20 Dr. Francois Béland, "New Generic Approach for HPLC analysis: "The Modern Silica-Based HPLC Columns; SiliaChrom Series"
15:20 - 16:00 Dr. Gert Hendriks (PRA Int.); "New Approach in Developing Bioanalytical Solid Phase Extraction Methods, with the SPE-connector".
16:00 - 16:45 Closing & Drinks at the bar
Speakers and Abstracts:
“Purifications in Process Chemistry” by Henkjan van Lent, B.Sc (MSD)
Abstract In this presentation the every day practice of purifications in the field of organic process chemistry is being presented. Milligram to kilogram purifications are performed on the lab using a broad array of equipment. Straight phase and functionalized silica’s are used, both in pre-packed columns and in open columns. Also the process of discriminating between columns of different suppliers is being presented."
Job description:After graduating in 1996 as a B.Sc. at the HLO in Utrecht (organic chemistry) Henkjan started working at Akzo Nobel Central Research in Deventer and Arnhem. In 1999 Akzo Nobel reorganized its research and his job became redundant. Fortunately he could continue working for Akzo Nobel at Diosynth in Oss as a development technician in API process development. In 2000 he continued his career a little upstream in the trajectory of pharmaceutical sciences at the Department of Process Chemistry (Organon) were he is currently working as a development assistant. His expertises include carbohydrate chemistry, heterocyclic chemistry and process development. In November 2007 Organon was taken over by Schering Plough and in November 2009 Schering Plough was taken over by MSD (Merck, Sharp & Dohme).
"Functionalized Silica's for Homogeneous Catalyst Recovery and Recycling" By Prof.dr.ir. André B. de Haan Eindhoven University of Technology
Abstract At the Eindhoven University of Technology we have applied functionalized silica’s for the recovery and recycling of homogeneous catalysts. These functionalized silica’s have been applied in new technology concept called Reverse Flow Adsorption for the process integrated catalyst recycling. During this presentation I will present an overview of the approach and results of the different development steps: adsorbent identification and characterization, adsorption kinetics, functionalized silica design and application to a palladium catalyzed Heck reaction.
Resume Prof.dr.ir. André B. de Haan studied Chemical Engineering at the Technical University of Delft and did his Ph.D. at the laboratory of Process Equipment at the same university under supervision of Prof. De Graauw. In the period 1991-1999 he worked for DSM Research in different positions and was appointed full professor in separation technology at the University Twente in 1999. Since September 2006 he is a full time professor Process Systems Engineering at the Eindhoven University of Technology. His research focuses on affinity solvent and affinity solid separation process systems engineering.
“New Approach in Developing Bioanalytical Solid Phase Extraction Methods” by Dr. Gert Henriks (PRA International)
Abstract “Solid Phase Extraction (SPE) is a widely used sample preparation technique for cleaning up or to concentrate bioanalytical samples, mostly blood plasma or urine. A generic SPE method is good in many occasions. However, when recovery is insufficient or extracts still contain interferences, the method has to be carefully developed. The usual procedure is to perform many extractions, while varying the type of sorbent , solvent composition and sometimes solvent volumes. A new approach in SPE method development is to determine the retention behaviour of the analytes on the actual SPE columns, either syringe barrel shaped or Waters µElution plate, by connecting this column to an LC system and to monitor the column effluent by a suitable detector (preferably a mass spectrometer). The resulting chromatograms can be used for screening different sorbents or to determine the optimal solvent composition and volume for washing and eluting the sample. The results can also be used to model the behaviour of the analytes on the SPE system and to predict the recovery / break through of each wash / elute step. This new approach is easy to automate and leads to optimal extraction conditions”.
Job description: Develop new assay methods for the determination of drugs and their metabolites or endogenous compounds for drug research. Investigate and implement new analytical techniques and equipment.
"Extraction, separation and concentration of watery flavour Distillates using column extraction". By B.Sc. Hans Colstee, (IFF)
Abstract:
Job description: Projectleader Organic Chemistry R&D, Netherlands, International Flavours & Fragrances Inc.
"Silica gel: from the earth to the lab". by Dr.Francois Béland (Vice - President Research & Development at Silicycle),
SiliCycle® is the leader in the development of functionalized silica gels, gathered under the name SiliaBond®, for use in chromatography and organic/synthetic chemistry. SiliCycle offers a wide range of products designed to expedite purification from the familiar such as flash silica to the innovative such as metal scavengers. SiliCycle is a specialist in the development and production of adsorbents for use in various chromatographic and synthetic applications that are widely used in all stages of drug development. Learn how silica gel is made and then how you can benefit from its functionalization in diverse applications related to organic/medicinal chemistry.
New Generic Approach for HPLC analysis: "The Modern Silica-Based HPLC Columns; SiliaChrom Series". By Vincent Bédard, Charles Lévesque and François Béland. Today, there are many HPLC columns on the market. Every year during the Pittcon conference, many vendors present new HPLC columns and now, choosing the right HPLC column is a big analytical challenge. The wrong HPLC column selection affects resolution, run time, quantification, and delays for final results. In addition, loss of money and of research contracts adds to the considerable stress in the laboratory resulting from a poor choice of HPLC column. Sometimes it is necessary to use computer simulation to find appropriate HPLC conditions such as DryLab. But computer simulation is a limited approach based on the detector used in the method. With the SiliaChrom HPLC columns Series, the scientific world has now a generic approach in HPLC. This family is designed for the most popular applications with the most relevant HPLC column chemistries. The family contains columns for LC-MS, for high water level (or buffer), for low and high pH, with very pure silica gel to avoid Lewis acids sites, with 3 different carbon loadings with high area surface to cover typical ratio of hydrophobicity and hydrophilicity, and a HILIC column for extremely polar analytes. The HPLC SiliaChrom Series is now a powerful family for any type of analytes for all types of detector. At SiliCycle, we constantly improve the quality of our silica gel support. Since 1995, we manufacture silica gel and now with our new spherical gel, we can produce HPLC columns at the highest quality and efficiency. The main goal for the SiliaChrom columns is to provide, to the HPLC end-user, the appropriate HPLC column for any type of applications. In this presentation, we present the SiliaChrom family with technical information for each columns, and finally HPLC data and comparison with other HPLC columns vendors.
Job description: François Béland is the Vice-president of R&D at SiliCycle Inc. He obtained his Ph.D. in 1999 from Laval University in Quebec City where he studied silica based catalysts by different spectroscopy methods. After getting his Ph.D. he went to Montpellier in the South of France for post-doctoral studies at the Ecole Nationale Superieure de Chimie de Montpellier. There he studied different catalytic reactions in organic chemistry catalyzed by silica-based heterogeneous catalysts. He started working at SiliCycle as a researcher after his post-doc. A year later he was promoted to R&D Director and his focus was to develop the SiliaBond (functionalized silica gels) product line. In 2006, he was also put in charge of marketing. Recently he has been named Vice-president of R&D. Dr. Béland has 14 years of experience with silica-based product for different applications in chromatography and organic chemistry. He gives seminars at customer’s sites worldwide and provides, with his group, technical support and training to the sales representatives, agents, distributors, and clients on all of SiliCycle’s product lines.